Analysis of Molecular Signaling Events Controlling Muscular Contraction in C. elegans

<p>The diagram shows the molecular components of the signaling pathways downstream of the muscarinic GPCRs in <i>C. elegans</i>. Alleles of genes encoding proteins in the pathway were tested for their effect on the Egl-d phenotype caused by treatment with BMS-192364. For the pathway members indicated by stars, certain alleles altered the response to treatment with BMS-192364. Specifically, resistance to the Egl-d phenotype was conferred by two gain-of-function alleles of <i>egl-19</i> and one of <i>egl-30,</i> and by two loss-of-function alleles of <i>eat-16</i> and one of <i>goa-1</i>.