Multiple-Sequence Alignment of 5′ <i>gag</i> Leader Nucleotide Sequences from XMRV and Related MuLVs

<p>Sequences extending from the alternative CUG start codon to the AUG start codon (underlined) of <i>gag</i> derived from XMRV VP35, VP42, and VP62 (blue); MTCR, MuLVs DG-75, and Friend; and a set of representative non-ecotropic proviruses (mERVs) were aligned with ClustalX (see <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.0020025#s4" target="_blank">Materials and Methods</a>). Predicted amino acid translation corresponding to the VP35 sequence is shown above the alignment (red); asterisk indicates a stop. Sequences are labeled as xenotropic (X), polytropic (P), modified polytropic (Pm), or ecotropic (E). Dots denote nt identical to those from XMRV, and deleted nt appear as spaces.