QQ Plot of <i>cis</i> versus <i>trans</i> HSA20 −log₁₀<i>p</i>-Values

<p>The figure shows the contrast of −log₁₀<i>p</i>-values deriving from associations of SNPs and genes within the 10-Mb region of HSA20 with −log₁₀<i>p</i>-values deriving from associations between genes on the 10-Mb region HSA20 with SNPs in one of ten ENCODE regions. Note that the distribution falls off the diagonal around −log₁₀<i>p</i> = 4, which we consider the borderline for the high enrichment of <i>cis</i> significant effects. A similar pattern is observed with any set of <i>trans</i> −log₁₀<i>p</i>-values on HSA20 or any other <i>cis</i> vs. <i>trans</i> contrast in any region we tested.