Summary of Quantitative Measurements of Changes in Volume Blood Flux in Response to Single Microvessel Occlusion and MCA Occlusion

<div><p>(A) Illustration showing topological relationship of vessels in (B) to (E) relative to the clotted arteriole (indicated with an X).</p> <p>(B–E) Histograms of the ratio of the post-clot flux to the baseline flux for vessels with different topological relationships to a photothrombotically clotted cortical surface arteriole: (B) upstream, (C) parallel, (D) first branch downstream, and (E) second to fourth branch downstream.</p> <p>(F) Histogram of the ratio of the flux measured during intra-luminal filament occlusion of the MCA to the baseline flux for cortical arterioles. In the interests of clarity, outliers with post-clot flux greater than twice the baseline flux were excluded from these histograms: one parallel vessel (ratio = 7), two D1 vessels (ratio = 2.5, 2.8), one D2 – 4 vessel (ratio = 11), and one filament occlusion vessel (ratio = 2.1). The arrows point to the mean values across all data points for each vessel class.</p>