Reduction of PGRP-SC1/2 Levels Sensitizes Larvae to Bacterial Infection

<div><p>(A) The percentage of dead larvae is measured 24 h after natural infection. Numbers in parentheses correspond to the total number of infected larvae. Each histogram corresponds to the mean value of six independent experiments (± standard deviation) for E. coli and five for <i>E. carotovora carotovora.</i> Asterisks indicate that the difference between <i>UAS iPGRP-SC</i> and <i>DaGal4;UAS iPGRP-SC</i> values is statistically significant (<i>p</i> < 0.05).</p><p>(B) The percentage of adults showing wing notching is measured 7 d after natural infection. Numbers in parentheses correspond to the total number of infected larvae.</p><p>(C–F) Natural infection with <i>E. carotovora carotorova</i> and E. coli triggers increased cell death and developmental defects in <i>DaGal4;UAS iPGRP-SC</i> flies. Wing imaginal discs dissected from <i>DaGal4;UAS iPGRP-SC</i> larvae (F) show higher levels of cell death after natural infection than discs from infected <i>UAS iPGRP-SC</i> control larvae (E). Consistently, some <i>DaGal4;UAS iPGRP-SC</i> adults derived from infected larvae exhibit wing notching (indicated by arrowheads) (D), which was never observed in infected controls (C).</p>