Interchromosomal Plots of LD Reveal the Presence of Putative Interaction Networks

<div><p>(A) A plot of the disequilibrium between pairs of SNP markers on mouse Chromosomes 14–17. Plot parameters are identical to <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0010033#pgen-0010033-g002" target="_blank">Figure 2</a>. The members of two mutually exclusive, and completely connected, putative interaction networks are highlighted with red and blue circles, chosen to correspond with the highly connected network cores shown in (B).</p><p>(B) A representation of two reduced, highly connected networks was created by restricting the edges to marker pairs with <i>D′</i> ≥ 0.8 and <i>p_FET</i> ≤ 10⁻³. To highlight only the most connected markers (nodes), the graph was reduced to show only nodes that were part of biconnected components (cliques) consisting of six or more nodes, and only components that include markers from Chromosomes 14–17, as shown in (A). Highlighted nodes correspond to the highlighted regions in (A).</p>