Modification Boundaries

<div><p>(A) H3K4Me3 boundaries occur across TSSs. The <i>x</i>-axis represents the level of H3K4Me3 for a given nucleosome, and the <i>y</i>-axis represents the level of this modification for the preceding nucleosome. Pairs of nucleosomes flanking the TSS for a gene on the W strand are plotted as blue squares, and pairs flanking TSSs for genes on the C strand are plotted as red squares. Remaining nucleosome pairs are plotted as grey circles.</p> <p>(B) Example of a punctate nucleosome. Histone modification plotted as in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030328#pbio-0030328-g001" target="_blank">Figure 1</a>B for a subset of histone modifications. Arrow indicates a nucleosome whose modification pattern differs significantly for H3K4Me3 from nucleosomes to either side. Gene names are as labelled.</p> <p>(C) Example of a punctate nucleosome, labelled as in (B).</p>