Atorvastatin Activates sAPP_α Shedding Out of Proportion to Its Effect on holoAPP or csAPP

<div><p>(A) SweAPP N2a cells were treated with atorvastatin (Atv) for 24 h and then surface biotinylation was performed as described in Methods. Evaluation of csAPP was performed by immunoprecipitation–immunoblot after surface biotinylation, while holoAPP and sAPP_α were evaluated by immunoblot as described in Methods. C, control.</p> <p>(B) Graphic representation of data. Y-axis shows effect of treatment (in arbitrary units) divided by effect of untreated control (in arbitrary units); <i>n</i> = 3 independent experiments; *, <i>p</i> < 0.05; **, <i>p</i> < 0.01; Student's <i>t</i> test).</p>