<div><p>(A) A 140-kb BAC from the <i>Gdf5</i> locus was modified by inserting <i>Cre</i>-IRES-<i>hPLAP</i> into the translation start site of <i>Gdf5</i> and used to make transgenic mice. Not to scale. See <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0020355#s4" target="_blank">Materials and Methods</a> for details.</p> <p>(B–E) Visualization of <i>Gdf5-Cre</i> driven recombination patterns based on activation of <i>lacZ</i> expression from the <i>R26R</i> Cre reporter allele. (B) LACZ activity is visible as blue staining in the ear (ea) and the joints of the shoulder (s), elbow (eb), wrist (w), knee (k), ankle (a), vertebra (vj), and phalanges (black arrowheads) of an E14.5 mouse embryo. (C) E14.5 h...
BACKGROUND: The use of the Cre/loxP system for gene targeting has been proven to be a powerful tool ...
AbstractThe Cre/loxPsite-specific recombination system combined with embryonic stem cell-mediated te...
AbstractThe origin, roles and fate of progenitor cells forming synovial joints during limb skeletoge...
Articular cartilage plays an essential role in health and mobility, but is frequently damaged or los...
<div><p>(A) Breeding strategy simultaneously deletes <i>Bmpr1a<sup>floxP</sup></i> and allows visual...
We have used an aggrecan gene enhancer to generate a transgenic murine line (Acan-CreER-Ires-Luc) ex...
To study the physiological control of osteoclasts, the bone resorbing cells, we generated transgenic...
<p>A tissue section from long bone of <i>Prx1Cre; RosaR</i> mice show intense LacZ staining in bone ...
<div><p>(A) Diagram of ankle bones from a wild-type mouse; bones fusing in mutant are colored red. R...
<p>(<b>A</b>) A typical agarose gel resulting from PCR genotyping of genomic DNA from tail biopsies ...
One of the goals of systems genetics is the reconstruction of gene networks that underlie key proces...
Conditional mutant mice equipped with heterologous recombination systems (Cre/lox or Flp/frt) are pr...
Background: Studies on osteoclasts, the bone resorbing cells, have remained limited due to the lack ...
Synovial joints are the most common joints facilitating skeletal movement. Healthy articular cartila...
BACKGROUND: Studies on osteoclasts, the bone resorbing cells, have remained limited due to the lack ...
BACKGROUND: The use of the Cre/loxP system for gene targeting has been proven to be a powerful tool ...
AbstractThe Cre/loxPsite-specific recombination system combined with embryonic stem cell-mediated te...
AbstractThe origin, roles and fate of progenitor cells forming synovial joints during limb skeletoge...
Articular cartilage plays an essential role in health and mobility, but is frequently damaged or los...
<div><p>(A) Breeding strategy simultaneously deletes <i>Bmpr1a<sup>floxP</sup></i> and allows visual...
We have used an aggrecan gene enhancer to generate a transgenic murine line (Acan-CreER-Ires-Luc) ex...
To study the physiological control of osteoclasts, the bone resorbing cells, we generated transgenic...
<p>A tissue section from long bone of <i>Prx1Cre; RosaR</i> mice show intense LacZ staining in bone ...
<div><p>(A) Diagram of ankle bones from a wild-type mouse; bones fusing in mutant are colored red. R...
<p>(<b>A</b>) A typical agarose gel resulting from PCR genotyping of genomic DNA from tail biopsies ...
One of the goals of systems genetics is the reconstruction of gene networks that underlie key proces...
Conditional mutant mice equipped with heterologous recombination systems (Cre/lox or Flp/frt) are pr...
Background: Studies on osteoclasts, the bone resorbing cells, have remained limited due to the lack ...
Synovial joints are the most common joints facilitating skeletal movement. Healthy articular cartila...
BACKGROUND: Studies on osteoclasts, the bone resorbing cells, have remained limited due to the lack ...
BACKGROUND: The use of the Cre/loxP system for gene targeting has been proven to be a powerful tool ...
AbstractThe Cre/loxPsite-specific recombination system combined with embryonic stem cell-mediated te...
AbstractThe origin, roles and fate of progenitor cells forming synovial joints during limb skeletoge...