Expression of CXCR3 in Lungs of Control and Emphysematous Smoker Individuals

<div><p>(A) Representative forward and side-scatter characteristics of whole lung cells from a participant with COPD and emphysema. Anti-CD11b PE-conjugated and anti-CD14 FITC-conjugated antibodies detect lung macrophages (middle), and histogram of mean fluorescence intensity showing anti-CXCR3-Cy5 and control antibodies (cIg) detects lung macrophages in the patient with emphysema.</p> <p>(B) Pooled data from control individuals without (<i>n =</i> 5) and with (<i>n =</i> 8) emphysema. Columns are median, bars represent SD. *, <i>p =</i> 0.009 (Mann-Whitney test) for the comparison of emphysema and control participants.</p> <p>(C) Negative association between CXCR3 expression on CD3⁺ T cells and FEV1 percentage predicted based on an <i>R²</i> goodness-of-fit statistic of 0.27 (<i>p =</i> 0.0089, <i>r</i> = −0.52, <i>n =</i> 24).</p>