<div><p>Computer model of gene network, scaled to <i>Drosophila</i> length (0.5 mm). Diffusion parameters are varied for mRNA (Dm), protein (Dp), and T7 activator (DX). Data are plotted as percentage of total output protein (y-axes) against chamber position (x-axes), for 10-min simulations.</p> <p>(A) Outputs for protein A.</p> <p>(B) Output for protein B. Graphs with “target behaviour” are shaded grey, and the four asterisks mark the parameter sets used to generate outputs for proteins A and C.</p> <p>(C) Outputs for protein C.</p> <p>(D) Effect of adding protease degradation to B-output, shown at 15-min intervals, over a 2.5-h time course (parameters: DX = 0.43 μm<sup>2</sup>s<sup>−1</sup>; ...
(a) The experimental abundance levels (solid line) and degradation rates (open circles) of the mouse...
The wonderful complexity of livings cells cannot be understood solely by studying one gene or protei...
<p>(<b>A</b>) The <i>Drosophila</i> network, the networks lacking (<b>B</b>) activation from <i>Kr</...
<p>The dynamics of expression levels of proteins {<i>P<sub>i</sub></i>(<i>t</i>)} with different par...
<div><p>Data are shown for the three gene networks described in <a href="http://www.plosbiology.org/...
It is well known that gene regulation is a tightly controlled process in early organismal developmen...
The yeast synthetic network was described by a system of nonlinear Delay Differential Equations (DDE...
<p>Indexes of variables are A (as in k<sub>A</sub>, V<sub>A</sub>) for control (+DMSO) and B (as in ...
<p>Upper panel: R protein degradation rate (and other parameters as described in the text) with the...
The development of accurate and reliable dynamical modeling procedures that describe the time evolut...
The development of accurate and reliable dynamical modeling procedures that describe the time evolut...
<p>Each step transition is determined by a rate constant. Promoter activation and inactivation occur...
<div><p>The development of accurate and reliable dynamical modeling procedures that describe the tim...
This is supplementary information for the main paper Reconstruction of transcriptional dynamics from...
Almost all processes in life are governed by proteins which are biomolecules consisting of a chain o...
(a) The experimental abundance levels (solid line) and degradation rates (open circles) of the mouse...
The wonderful complexity of livings cells cannot be understood solely by studying one gene or protei...
<p>(<b>A</b>) The <i>Drosophila</i> network, the networks lacking (<b>B</b>) activation from <i>Kr</...
<p>The dynamics of expression levels of proteins {<i>P<sub>i</sub></i>(<i>t</i>)} with different par...
<div><p>Data are shown for the three gene networks described in <a href="http://www.plosbiology.org/...
It is well known that gene regulation is a tightly controlled process in early organismal developmen...
The yeast synthetic network was described by a system of nonlinear Delay Differential Equations (DDE...
<p>Indexes of variables are A (as in k<sub>A</sub>, V<sub>A</sub>) for control (+DMSO) and B (as in ...
<p>Upper panel: R protein degradation rate (and other parameters as described in the text) with the...
The development of accurate and reliable dynamical modeling procedures that describe the time evolut...
The development of accurate and reliable dynamical modeling procedures that describe the time evolut...
<p>Each step transition is determined by a rate constant. Promoter activation and inactivation occur...
<div><p>The development of accurate and reliable dynamical modeling procedures that describe the tim...
This is supplementary information for the main paper Reconstruction of transcriptional dynamics from...
Almost all processes in life are governed by proteins which are biomolecules consisting of a chain o...
(a) The experimental abundance levels (solid line) and degradation rates (open circles) of the mouse...
The wonderful complexity of livings cells cannot be understood solely by studying one gene or protei...
<p>(<b>A</b>) The <i>Drosophila</i> network, the networks lacking (<b>B</b>) activation from <i>Kr</...