Female PGC-1α^−/− Mice Are More Glucose Tolerant and Insulin Sensitive Compared to PGC-1α^+/+ on High-Fat Diet

<div><p>(A) At 4.5 mo of age, glucose tolerance testing (GTT) was performed on female PGC-1α^+/+ (<i>n</i> = 6) and PGC-1α^−/− (<i>n</i> = 6) mice maintained on standard chow.</p> <p>(B) At 8 wk of age, PGC-1α^+/+ (<i>n</i> = 8) and PGC-1α^−/− (<i>n</i> = 11) mice were provided a diet containing 43% of its calories from fat (HF chow). The graphs depict blood glucose levels ± SEM in PGC-1α^−/− mice during GTT (left graph) and ITT (right graph) studies. Studies were performed 5 wk (GTT) and 6 wk (ITT) after the initiation of the high-fat diet. * <i>p</i> < 0.05 compared to PGC-1α^+/+ mice at the same time point.</p>