Evolution of HIV-1-Specific CD4+ and CD8+ T Cell Responses during STI

<div><p>(A–D) Magnitude and breadth of increase of HIV-specific CD8+ T cells during supervised treatment interruptions.</p> <p>(A and B) Magnitude (A) and breadth (B) of HIV-specific CD8+ responses at the first day of treatment interruption (black bars) and at the last day off therapy (white bars). Data represent the mean and standard deviation.</p> <p>(C and D) Correlation between the increase of the magnitude (C) or breadth (D) of CD8+ T cell responses and the time off therapy during the first treatment interruption.</p> <p>(E and F) Evolution of CD4+ T helper cell responses during supervised treatment interruptions.</p> <p>(E) Magnitude of CD4 T helper cell responses at baseline and at the first day of treatment interruption (closed circles) and last day off therapy (open circles). Horizontal bars correspond to median values. An stimulation index greater than five was considered significant.</p> <p>(F) Correlation between the magnitude of p24-specific lymphocyte proliferative responses at the beginning of the first treatment interruption and the time patients were able to remain off therapy during the subsequent STI.</p>