<p>CTL clones derived from each patient were classified as “efficient” (greater than 40%), “intermediate” (between 10% and 40%), or “low/no” (less than 10%) in lysis of melanoma cells based on data displayed in <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0010028#pmed-0010028-g002" target="_blank">Figure 2</a>. Each bar represents the portion of total clones from each patient with “efficient,” “intermediate,” or “low/no” melanoma lysis potential.</p
Tumor antigen-specific cytotoxic T cells (CTLs) play a major role in the adaptive immune response to...
International audienceUnderstanding the human cytotoxic T lymphocyte (CTL) biology is crucial to dev...
<p>For each graph, the number of independent clones (blue bars) or the total aggregate number of cel...
<p>Cells from 87 clonal CTL lines were assayed for lysis of melanoma cells mel526, Malme-3M, and A37...
<p>Cytotoxicity of selected CD8+ T cell clones from (A) healthy donor, (B) melanoma patient A02, and...
International audienceTo better understand how Ag density influences the various biologic responses ...
Limiting numbers of peripheral-blood mononuclear cells (PBMC) from melanoma patients were stimulated...
Adoptive immunotherapy using CTL has provided some clinical benefit to patients with metastatic mela...
a<p> Number of growing clones, percentage of wells seeded in brackets.</p>b<p> Number of clones prod...
<p>CTL clones 476.105 and 132.1 were assayed for lysis of T2 cells pulsed with 10-fold dilutions of ...
Anti-melanoma cytolytic T-lymphocyte (CTL) clones were derived from peripheral blood lymphocytes of ...
International audienceWe reported previously that a large fraction of melanoma cell lines induced a ...
Anti-melanoma cytolytic T-lymphocyte (CTL) clones were derived from peripheral blood lymphocytes of ...
Anti-melanoma cytolytic T-lymphocyte (CTL) clones were derived from peripheral blood lymphocytes of ...
<div><p>CTL clones representing different tetramer-positive populations in each patient expressing d...
Tumor antigen-specific cytotoxic T cells (CTLs) play a major role in the adaptive immune response to...
International audienceUnderstanding the human cytotoxic T lymphocyte (CTL) biology is crucial to dev...
<p>For each graph, the number of independent clones (blue bars) or the total aggregate number of cel...
<p>Cells from 87 clonal CTL lines were assayed for lysis of melanoma cells mel526, Malme-3M, and A37...
<p>Cytotoxicity of selected CD8+ T cell clones from (A) healthy donor, (B) melanoma patient A02, and...
International audienceTo better understand how Ag density influences the various biologic responses ...
Limiting numbers of peripheral-blood mononuclear cells (PBMC) from melanoma patients were stimulated...
Adoptive immunotherapy using CTL has provided some clinical benefit to patients with metastatic mela...
a<p> Number of growing clones, percentage of wells seeded in brackets.</p>b<p> Number of clones prod...
<p>CTL clones 476.105 and 132.1 were assayed for lysis of T2 cells pulsed with 10-fold dilutions of ...
Anti-melanoma cytolytic T-lymphocyte (CTL) clones were derived from peripheral blood lymphocytes of ...
International audienceWe reported previously that a large fraction of melanoma cell lines induced a ...
Anti-melanoma cytolytic T-lymphocyte (CTL) clones were derived from peripheral blood lymphocytes of ...
Anti-melanoma cytolytic T-lymphocyte (CTL) clones were derived from peripheral blood lymphocytes of ...
<div><p>CTL clones representing different tetramer-positive populations in each patient expressing d...
Tumor antigen-specific cytotoxic T cells (CTLs) play a major role in the adaptive immune response to...
International audienceUnderstanding the human cytotoxic T lymphocyte (CTL) biology is crucial to dev...
<p>For each graph, the number of independent clones (blue bars) or the total aggregate number of cel...