The Tumor Spectrum in Fish Heterozygous for Mutations in RP Genes Shows an Increased Proportion of zMPNSTs

<p>Fish with apparent masses were selected and processed for histological analysis. Numbers are shown as percent of the total number of diagnosed tumors from either population. The control group includes 42 tumors from 41 fish, including both wild-type and non-RP family transgenics. The RP group includes 68 tumors from 65 RP heterozygotes from 18 different lines representing mutations in 16 different genes. The “other” tumor category includes pancreatic islet adenomas, ultimobranchial gland tumors, neuroblastomas, retinoblastomas, lymphomas, ganglioneuromas, ductal carcinomas, gastrointestinal adenocarcinomas, hepatocellular carcinomas, leukemias, meningiomas, and histiocytic sarcomas.