<p>In the absence of the Wnt ligand, Arm/ β-catenin (β) is phosphorylated by a complex of Axin, APC, and Zw3/GSK3 β and rapidly degraded. Upon Wnt (W) signaling through the Frizzled receptor and Dsh, this complex is inhibited: as a consequence, β-catenin accumulates and binds to LEF/TCF proteins to stimulate transcription of Wnt target genes.</p
The Canonical Wnt signaling pathway (Wnt/beta-catenin pathway) is required during embryonic developm...
Degradation of cytosolic beta-catenin by the APC/Axin1 destruction complex represents the key regula...
<p>Wnt binding brings together the receptor Fz and the co-receptor Arrow/LRP5 or 6 extra-cellularly....
<p>(A) In the absence of an external WNT stimulus β-catenin (referred to by its official gene name C...
<p>The left side of the model indicates components of the classic Wnt/Frizzled mediated activation o...
<p>Drugs used in the experiments and their action on Wnt signaling pathways are figured in black. Ac...
<div><p>Wnt signaling plays an important role in both oncogenesis and development. Activation of the...
Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of cytoplas-mic b-c...
Degradation of cytosolic β-catenin by the APC/Axin1 destruction complex represents the key regulated...
SummaryDegradation of cytosolic β-catenin by the APC/Axin1 destruction complex represents the key re...
In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which i...
In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which i...
In the absence of a Wnt signal ß-catenin is phosphorylated by GSK3-ß, in a complex also containing A...
Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pat...
In the absence of a Wnt signal ß-catenin is phosphorylated by GSK3-ß, in a complex also containing A...
The Canonical Wnt signaling pathway (Wnt/beta-catenin pathway) is required during embryonic developm...
Degradation of cytosolic beta-catenin by the APC/Axin1 destruction complex represents the key regula...
<p>Wnt binding brings together the receptor Fz and the co-receptor Arrow/LRP5 or 6 extra-cellularly....
<p>(A) In the absence of an external WNT stimulus β-catenin (referred to by its official gene name C...
<p>The left side of the model indicates components of the classic Wnt/Frizzled mediated activation o...
<p>Drugs used in the experiments and their action on Wnt signaling pathways are figured in black. Ac...
<div><p>Wnt signaling plays an important role in both oncogenesis and development. Activation of the...
Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of cytoplas-mic b-c...
Degradation of cytosolic β-catenin by the APC/Axin1 destruction complex represents the key regulated...
SummaryDegradation of cytosolic β-catenin by the APC/Axin1 destruction complex represents the key re...
In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which i...
In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which i...
In the absence of a Wnt signal ß-catenin is phosphorylated by GSK3-ß, in a complex also containing A...
Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pat...
In the absence of a Wnt signal ß-catenin is phosphorylated by GSK3-ß, in a complex also containing A...
The Canonical Wnt signaling pathway (Wnt/beta-catenin pathway) is required during embryonic developm...
Degradation of cytosolic beta-catenin by the APC/Axin1 destruction complex represents the key regula...
<p>Wnt binding brings together the receptor Fz and the co-receptor Arrow/LRP5 or 6 extra-cellularly....
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