CDSC-Pax7 Cells Efficiently Contribute to the Repair of Dystrophic Muscle

<div><p>(A) Wild-type muscle expressed dystrophin at the plasmalemma of all myofibers.</p> <p>(B) Dystrophin protein was not detected in muscle sections from <i>dystrophin</i>-deficient <i>mdx:nude</i> mice <i>(mdx:nu).</i></p> <p>(C–F) CDSC-Pax7 cells differentiated in vivo after transplantation, readily forming large numbers of dystrophin-expressing myofibers (green) in <i>mdx:nude</i> muscle (C and D). Serial cross sections showing the viral expression of Pax7 protein in central nuclei of regenerated fibers (red staining in [E]) confirmed the donor origin of dystrophin-positive myofibers (red staining in [F]).</p>