Regulation of Longevity by CR and Fob1

<div><p>(A) Life span analysis for three genetic models of CR and deletion of <i>FOB1</i>. Strains shown (and mean life spans) are BY4742 (26.7), <i>fob1Δ</i> (37.8), <i>gpa2Δ</i> (34.9), <i>gpr1</i> (34.4), and <i>hxk2Δ</i> (36.7).</p> <p>(B) <i>fob1Δ</i> and <i>hxk2Δ</i> increase life span additively. Strains shown (and mean life spans) are BY4742 (26.6), <i>fob1Δ</i> (37.3), <i>hxk2Δ</i> (36.7), and <i>fob1Δ hxk2Δ</i> (48.3).</p> <p>(C) <i>fob1Δ</i> and <i>gpa2Δ</i> increase life span additively. Strains shown (and mean life spans) are BY4742 (27.2), <i>fob1Δ</i> (37.8), <i>gpa2Δ</i> (36.7), and <i>fob1Δ gpa2Δ</i> (54.5).</p>