Study Design
- Inês Barroso (2144)
- Jian'an Luan (2145)
- Rita P. S Middelberg (2146)
- Anne-Helen Harding (2147)
- Paul W Franks (2148)
- Rupert W Jakes (2149)
- David Clayton (2150)
- Alan J Schafer (2151)
- Stephen O'Rahilly (2152)
- Nicholas J Wareham (2153)
Publication date
February 2013
DOIAbstract
<p>Candidate genes were selected based on known or putative function. A de novo polymorphism discovery step was undertaken to identify novel variants for association studies. We selected 152 SNPs and tested them in a case-control study and a QT study. Association analysis with Type 2 diabetes was done for SNPs and haplotypes under multiple genetic models. Only SNPs and haplotypes associated with disease were evaluated for association with five diabetes-related QTs under the same model in the QT study.</p
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