LOH of Wild-Type <i>p19^Arf</i> Allele in <i>p19^Arf+/−</i> Tumors

<div><p>(A) LOH analysis by semiquantitative PCR of the wild-type <i>p19^Arf</i> allele in <i>p19^Arf+/−</i> papillomas and carcinomas. Gradient made from kidney DNA used for quantitation of wt/mu ratio (top row). wt, wild-type allele; mu, knockout allele; asterisk, loss or reduction of <i>p19^Arf</i> wild-type band.</p> <p>(B) Western blot analysis of nuclear lysates from papillomas (PA) and carcinomas (CA) from <i>p19^Arf+/+, p19^Arf+/−,</i> and <i>p19^Arf−/−</i> mice.</p>