Tumor Suppression by HIF2α shRNA Is Not Restricted to a Single Cell Line | ORKG Ask

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Antitumor activity of the cocktail treatment of Notch-siRNA and H101.

Yuting Yao (130315)
Li Wang (15202)
He Zhang (130319)
Haibo Wang (130324)
Xiaoping Zhao (130328)
Yidan Zhang (130332)
Leilei Zhang (130338)
Xianqun Fan (130343)
Guanxiang Qian (130346)
Ji-Fan Hu (130349)
Shengfang Ge (130352)

October 2012

<p>A. HeLa-S3 xenograft tumors in nude mice. Average volume of subcutaneous tumors after treatment w...

Tumor growth of human breast cancer cell lines in Rag2<sup>−/−</sup>;Il2rg<sup>−/−</sup>, but not in nude mice.

Patrizia Nanni (278845)
Giordano Nicoletti (278852)
Arianna Palladini (278849)
Stefania Croci (278851)
Annalisa Murgo (318536)
Marianna L. Ianzano (318537)
Valentina Grosso (119662)
Valeria Stivani (318538)
Agnese Antognoli (318539)
Alessia Lamolinara (318540)
Lorena Landuzzi (278853)
Emmanuelle di Tomaso (318544)
Manuela Iezzi (222621)
Carla De Giovanni (278847)
Pier-Luigi Lollini (278855)

February 2013

<p>Abbreviations: wk, weeks; SEM, standard error of the mean.</p>a<p>Tumor volumes at 12–13 weeks af...

Tumor growth in metformin/FuOx treated SCID mice injected with CR HCT-116 (left pane) or CR HT-29 cells (right panel) (A).

Pratima Nangia-Makker (511071)
Yingjie Yu (281567)
Anita Vasudevan (511072)
Lulu Farhana (411956)
Sindhu G. Rajendra (511073)
Edi Levi (425864)
Adhip P. N. Majumdar (511074)

January 2014

<p>Bars represent mean ± standard error. * p >0.05. Real time quantitative PCR on RNA extracted from...

Effect of HIF2α shRNA Is Specifically Due to Downregulation of HIF2α

Keiichi Kondo (70327)
William Y Kim (70328)
Mirna Lechpammer (70329)
William G Kaelin Jr (380675)

February 2013

<div><p>(A) Parental 786-O cells (<i>VHL</i>[−/−]) and 786-O cells stably producing HIF2α shRNA #3 t...

Downregulation of HIF2α Is Sufficient to Suppress Tumor Growth by pVHL-Defective Renal Carcinoma Cells

Keiichi Kondo (70327)
William Y Kim (70328)
Mirna Lechpammer (70329)
William G Kaelin Jr (380675)

February 2013

<div><p>(A) Parental 786-O cells (<i>VHL</i>[−/−]) and 786-O cells infected with an empty retrovirus...

HIF2α Overrides Tumor Suppression by pVHL

Keiichi Kondo (70327)
William Y Kim (70328)
Mirna Lechpammer (70329)
William G Kaelin Jr (380675)

February 2013

<div><p>(A) 786-O subclones that were transfected to produce wild-type pVHL (WT8) or with an empty p...

Tumorigenesis by RasVal12 in NIH3T3 cells infected with an empty vector (C) or with a retrovirus carrying an shRNA specific for <i>MYBBP1A</i> (Sh3).

Silvia Mori (129700)
Rosa Bernardi (129706)
Audrey Laurent (129711)
Massimo Resnati (129717)
Ambra Crippa (129722)
Arianna Gabrieli (129726)
Rebecca Keough (129730)
Thomas J. Gonda (112865)
Francesco Blasi (61418)

October 2012

#<p>Total number of mice in the group.</p>○<p>volume expressed in cm<sup>3</sup>.</p>*<p>SEM = Stand...

TS and gentian violet reduce tumor volume in a SCID mouse xenograft model of MM.

Brian Cunniff (318304)
Kheng Newick (318303)
Kimberly J. Nelson (745486)
Alexandra N. Wozniak (745487)
Stacie Beuschel (745488)
Bruce Leavitt (745489)
Anant Bhave (745490)
Kelly Butnor (745491)
Andreas Koenig (368544)
Edward T. Chouchani (547616)
Andrew M. James (537246)
Alexina C. Haynes (745492)
W. Todd Lowther (202207)
Michael P. Murphy (401146)
Arti Shukla (318308)
Nicholas H. Heintz (745493)

May 2015

<p>(A) Hematoxylin and eosin (H&E) stained tumor tissue isolated from the peritoneal cavity of a DMS...

Rab7 shRNA expressing tumors grow larger, demonstrate increased cell proliferation, and decreased apoptosis <i>in vivo</i>.

Joshua J. Steffan (308023)
Samantha S. Dykes (520465)
David T. Coleman (520466)
Lisa K. Adams (303904)
Donna Rogers (520467)
Jennifer L. Carroll (303911)
B. Jill Williams (520468)
James A. Cardelli (520469)

February 2014

<p>A) SCID/Bg mice were injected with 2×10<sup>6</sup> NT shRNA (n = 6) or Rab7 shRNA (n = 7) expres...

Antitumor activity of the cocktail treatment of Notch-siRNA and H101.

Yuting Yao (130315)
Li Wang (15202)
He Zhang (130319)
Haibo Wang (130324)
Xiaoping Zhao (130328)
Yidan Zhang (130332)
Leilei Zhang (130338)
Xianqun Fan (130343)
Guanxiang Qian (130346)
Ji-Fan Hu (130349)
Shengfang Ge (130352)

October 2012

<p>A. HeLa-S3 xenograft tumors in nude mice. Average volume of subcutaneous tumors after treatment w...

Tumor growth of human breast cancer cell lines in Rag2<sup>−/−</sup>;Il2rg<sup>−/−</sup>, but not in nude mice.

Patrizia Nanni (278845)
Giordano Nicoletti (278852)
Arianna Palladini (278849)
Stefania Croci (278851)
Annalisa Murgo (318536)
Marianna L. Ianzano (318537)
Valentina Grosso (119662)
Valeria Stivani (318538)
Agnese Antognoli (318539)
Alessia Lamolinara (318540)
Lorena Landuzzi (278853)
Emmanuelle di Tomaso (318544)
Manuela Iezzi (222621)
Carla De Giovanni (278847)
Pier-Luigi Lollini (278855)

February 2013

<p>Abbreviations: wk, weeks; SEM, standard error of the mean.</p>a<p>Tumor volumes at 12–13 weeks af...

Tumor growth in metformin/FuOx treated SCID mice injected with CR HCT-116 (left pane) or CR HT-29 cells (right panel) (A).

Pratima Nangia-Makker (511071)
Yingjie Yu (281567)
Anita Vasudevan (511072)
Lulu Farhana (411956)
Sindhu G. Rajendra (511073)
Edi Levi (425864)
Adhip P. N. Majumdar (511074)

January 2014

<p>Bars represent mean ± standard error. * p >0.05. Real time quantitative PCR on RNA extracted from...

Tumorigenesis by RasVal12 in NIH3T3 cells infected with an empty vector (C) or with a retrovirus carrying an shRNA specific for <i>MYBBP1A</i> (Sh3).

Silvia Mori (129700)
Rosa Bernardi (129706)
Audrey Laurent (129711)
Massimo Resnati (129717)
Ambra Crippa (129722)
Arianna Gabrieli (129726)
Rebecca Keough (129730)
Thomas J. Gonda (112865)
Francesco Blasi (61418)

October 2012

#<p>Total number of mice in the group.</p>○<p>volume expressed in cm<sup>3</sup>.</p>*<p>SEM = Stand...

TS and gentian violet reduce tumor volume in a SCID mouse xenograft model of MM.

Brian Cunniff (318304)
Kheng Newick (318303)
Kimberly J. Nelson (745486)
Alexandra N. Wozniak (745487)
Stacie Beuschel (745488)
Bruce Leavitt (745489)
Anant Bhave (745490)
Kelly Butnor (745491)
Andreas Koenig (368544)
Edward T. Chouchani (547616)
Andrew M. James (537246)
Alexina C. Haynes (745492)
W. Todd Lowther (202207)
Michael P. Murphy (401146)
Arti Shukla (318308)
Nicholas H. Heintz (745493)

May 2015

<p>(A) Hematoxylin and eosin (H&E) stained tumor tissue isolated from the peritoneal cavity of a DMS...

Rab7 shRNA expressing tumors grow larger, demonstrate increased cell proliferation, and decreased apoptosis <i>in vivo</i>.

Joshua J. Steffan (308023)
Samantha S. Dykes (520465)
David T. Coleman (520466)
Lisa K. Adams (303904)
Donna Rogers (520467)
Jennifer L. Carroll (303911)
B. Jill Williams (520468)
James A. Cardelli (520469)

February 2014

<p>A) SCID/Bg mice were injected with 2×10<sup>6</sup> NT shRNA (n = 6) or Rab7 shRNA (n = 7) expres...

Antitumor activity of the cocktail treatment of Notch-siRNA and H101.

Yuting Yao (130315)
Li Wang (15202)
He Zhang (130319)
Haibo Wang (130324)
Xiaoping Zhao (130328)
Yidan Zhang (130332)
Leilei Zhang (130338)
Xianqun Fan (130343)
Guanxiang Qian (130346)
Ji-Fan Hu (130349)
Shengfang Ge (130352)

October 2012

<p>A. HeLa-S3 xenograft tumors in nude mice. Average volume of subcutaneous tumors after treatment w...

Tumor growth of human breast cancer cell lines in Rag2<sup>−/−</sup>;Il2rg<sup>−/−</sup>, but not in nude mice.

Patrizia Nanni (278845)
Giordano Nicoletti (278852)
Arianna Palladini (278849)
Stefania Croci (278851)
Annalisa Murgo (318536)
Marianna L. Ianzano (318537)
Valentina Grosso (119662)
Valeria Stivani (318538)
Agnese Antognoli (318539)
Alessia Lamolinara (318540)
Lorena Landuzzi (278853)
Emmanuelle di Tomaso (318544)
Manuela Iezzi (222621)
Carla De Giovanni (278847)
Pier-Luigi Lollini (278855)

February 2013

<p>Abbreviations: wk, weeks; SEM, standard error of the mean.</p>a<p>Tumor volumes at 12–13 weeks af...

Tumor growth in metformin/FuOx treated SCID mice injected with CR HCT-116 (left pane) or CR HT-29 cells (right panel) (A).

Pratima Nangia-Makker (511071)
Yingjie Yu (281567)
Anita Vasudevan (511072)
Lulu Farhana (411956)
Sindhu G. Rajendra (511073)
Edi Levi (425864)
Adhip P. N. Majumdar (511074)

January 2014

<p>Bars represent mean ± standard error. * p >0.05. Real time quantitative PCR on RNA extracted from...