Cross-talk degree in a module-level network is correlated with module essentiality.

<p>For either (a) protein complexes or (b) filtered biological processes, the fraction of modules containing at least one essential protein among “hub modules” tends to decrease in each network as more modules are considered hubs. For the data shown, modules are added in groups of 20 in a non-increasing order of cross-talk degree in the <i>Direct</i> (blue), <i>Pull-down</i> (cyan) and <i>Full</i> (purple) networks. Correlations computed using the SRCC are shown for each network between the binary essentiality of a module and its inferred cross-talk degree. The binary essentiality for a module is 1 if the module has at least one essential protein, and 0 otherwise.