A scheme showing estrogen-induced ROS transduce signals to the nucleus for the activation of transcription factor NRF-1 to regulate their downstream target genes involved in cell transformation and cell cycle presumably through a redox-sensitive AKT pathway.

<p>A scheme showing estrogen-induced ROS transduce signals to the nucleus for the activation of transcription factor NRF-1 to regulate their downstream target genes involved in cell transformation and cell cycle presumably through a redox-sensitive AKT pathway.