<p>a) Template D167. b) Template D387. Each column represents the reaction time for that simulation. The intensity of the bands is proportional to the amount of produced transcripts of that length in the allowed time. The experimental results shown here are graphical reproductions of the gels presented in the experimental work of Bai and Wang <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057328#pone.0057328-Bai3" target="_blank">[23]</a>. The experimentally observed bands are indicated with their respective transcript size. Some false positives present in the <i>SRA</i> appear less intense in the <i>MRA</i>. For the single-round and the multi-round elongation: some bands appear earlier in <i>MRA</i> than in <i>SRA</...
<p>When the model is fitted to multiple data sets with different starting genes, the transcript leve...
<p>Histograms of 10,000 realisations at time , as fractions of largest value: for a) autoregulated R...
<p>(A) The template, (−)-RNA1<sub>1–201</sub> with its 3′-end blocked, was incubated with the MBP-Pr...
<p><b>(A)</b> Transcriptional bursting (red dashed box) occurs when a promoter stochastically switch...
<p>The panels show the amount in individual cells (dots), and an interpolated contour plot of the 2D...
<p>(A) <i>In vitro</i> transcription was performed using the pfMC2AT templates harboring a G-free ca...
<p>(A) The number of state transitions depends on the background noise σ<sub>N</sub>. In the bistabl...
<p>Panels on columns 1, 2 and black lines of panels on column 3 correspond to the RM, where bound TF...
AbstractIn the companion article, we developed a modular scheme for representing the kinetics of tra...
<p>The lines and discrete dots correspond to analytical results and MC simulations, respectively. Th...
<p>a) Schematic of the simple synthetic circuit. b-g) Dose-response relationships for <i>t</i> = 65 ...
<p>Time for the active form (TR*) to reach a threshold is registered versus the time difference betw...
By the half-vs-half (split-cell) simulations (curves with data points shown), and compared to actual...
<p>StochPy plots of simulating stochastic gene expression. (A) long lifetimes of both the ON and OFF...
<p>(A) Top: Schematic of GAL1pr-YFP transcriptional reporter and cartoon of fluorescence distributio...
<p>When the model is fitted to multiple data sets with different starting genes, the transcript leve...
<p>Histograms of 10,000 realisations at time , as fractions of largest value: for a) autoregulated R...
<p>(A) The template, (−)-RNA1<sub>1–201</sub> with its 3′-end blocked, was incubated with the MBP-Pr...
<p><b>(A)</b> Transcriptional bursting (red dashed box) occurs when a promoter stochastically switch...
<p>The panels show the amount in individual cells (dots), and an interpolated contour plot of the 2D...
<p>(A) <i>In vitro</i> transcription was performed using the pfMC2AT templates harboring a G-free ca...
<p>(A) The number of state transitions depends on the background noise σ<sub>N</sub>. In the bistabl...
<p>Panels on columns 1, 2 and black lines of panels on column 3 correspond to the RM, where bound TF...
AbstractIn the companion article, we developed a modular scheme for representing the kinetics of tra...
<p>The lines and discrete dots correspond to analytical results and MC simulations, respectively. Th...
<p>a) Schematic of the simple synthetic circuit. b-g) Dose-response relationships for <i>t</i> = 65 ...
<p>Time for the active form (TR*) to reach a threshold is registered versus the time difference betw...
By the half-vs-half (split-cell) simulations (curves with data points shown), and compared to actual...
<p>StochPy plots of simulating stochastic gene expression. (A) long lifetimes of both the ON and OFF...
<p>(A) Top: Schematic of GAL1pr-YFP transcriptional reporter and cartoon of fluorescence distributio...
<p>When the model is fitted to multiple data sets with different starting genes, the transcript leve...
<p>Histograms of 10,000 realisations at time , as fractions of largest value: for a) autoregulated R...
<p>(A) The template, (−)-RNA1<sub>1–201</sub> with its 3′-end blocked, was incubated with the MBP-Pr...