Effects of Tanshinone IIA on the expression of p27 in pulmonary arteries in HPH rats.

<p>Representative western blot for p27 protein (A) and agarose gel electrophoresis for RT-PCR products of p27 mRNA (B) in pulmonary arteries from control and HPH rats. Beta-actin was used as control. Summarized data are shown in the bottom respectively. Hypoxia significantly decreased p27 protein level in pulmonary arteries and tanshinone IIA (10 mg/kg/day⁾ significantly reversed the hypoxia-induced p27 protein reduction (*P<0.05 vs normoxia group, # P<0.05 vs hypoxia group, mean ± SEM, n = 3). Hypoxia and tanshinone IIA did not significantly affect p27 mRNA level in pulmonary arteries in HPH rats.