<i>C. elegans</i> RNAi screen to identify H3K56me3-specific KMTs.

<p>Shown are representative IF images from adult <i>C. elegans</i> hermaphrodite somatic intestinal nuclei following RNAi treatment. H3K56me3 (left) or H3K9me3 (right) staining is shown in green and DAPI (DNA) is shown in blue. CAPG-1 co-staining was used as a staining control (data not shown). Results show that <i>met-1</i> and <i>met-2</i> depletion severely affect both H3K56me3 and H3K9me3, while reduction of additional KMTs (<i>set-6, set-25</i> and <i>set-32</i>) has a stronger effect on H3K56me3 levels compared to H3K9me3. Scale bar = 5 µm.