Male <i>Csf1r^+/−</i> mice show less colonic epithelial damage compared to WT male mice.

<p>(A) Colons were separated into proximal and distal regions and stained with H & E, (Bar = 100 µm). (<b>B</b>) Crypt damage is more severe in the distal colon compared to proximal regions and is more severe in WT mice. Colonic crypt damage in each section (Tissue Disease Activity Index) was graded according to the modified criteria of Dieleman <i>et al</i> (1998) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056951#pone.0056951-Dieleman1" target="_blank">[34]</a>, as described in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056951#s4" target="_blank">Methods</a> (n = 4, <b>**</b>P<0.01; <b>***</b>P<0.001;data analyzed using two-tailed t-tests).