Nocifensive behavior to mechanical, heat or cold stimulation of the whisker pad skin in sham and ION-CCI rats.

<p>Time-course change in the head-withdrawal threshold to mechanical stimulation of the whisker pad skin (A), head-withdrawal latency to heat stimulation of the whisker pad skin (B) and face scratching frequency following acetone application to the whisker pad skin (C). Ipsi. to CCI: ipsilateral side to CCI, Contra. to CCI: contralateral side to CCI, Ipsi. to sham: ipsilateral side to sham operation, before: before ION-CCI or sham operation. *: p<0.05 (vs. before), **: p<0.01 (vs. before).