Effect of high fructose consumption in WT mice and SGLT5-deficient mice.

<p>(A) Plasma glucose levels of WT mice (+/+) and SGLT5-deficient mice (−/−) were measured every 2 weeks. <i>HF</i>: Mice given water containing high fructose. (B) Growth curves of WT mice and SGLT5-deficient mice. (C) Plasma samples were collected after 6 h fasting at 21 weeks of age, and immunoreactive insulin (<i>IRI</i>) was determined. (D) Plasma fructose concentrations measured in plasma samples collected under anesthesia after 3 h fasting. <i>Open circles</i> represent individual data. (E and F) WT mice and SGLT5-deficient mice given plain water or fructose water were maintained in metabolic cages and 24-h urine samples were collected. Urinary fructose excretion was calculated by multiplying urinary fructose concentration by the amount of urine. Data are presented as means ± S.E.M (<i>n</i> = 8–10). *** <i>P</i><0.001 versus WT mice given 30% fructose water. # <i>P</i><0.05, ## <i>P</i><0.01, ### <i>P</i><0.001 versus respective plain water controls. +++ <i>P</i><0.001 versus WT mice given plain water.