Inhibition of the TGFβ pathway suppressed the fibroblastic change of HCECs.
- Naoki Okumura (258425)
- EunDuck P. Kay (381940)
- Makiko Nakahara (381941)
- Junji Hamuro (381942)
- Shigeru Kinoshita (93123)
- Noriko Koizumi (381943)
Publication date
February 2013
DOIAbstract
<p>(A) HCECs cultured with SB431542 (1 μM) exhibited the hexagonal cell shape and contact-inhibited monolayer, while the control CECs exhibited the fibroblastic morphology. (B+C) Both neutralizing antibody to TGF-β (500 ng/ml) and Smad3 inhibitor (3 mM) blocked cells from acquiring fibroblastic phenotypes. Scale bar: 50 μm. The experiment was performed in duplicate.</p
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