Clonogenic survival assays for siRNA transfected OVCAR-3 cells treated with cisplatin alone or in combination with NU6027 is shown here (A).

<p><b>B.</b> XRCC1 deficient cells accumulate significantly higher γH2AX foci compared to XRCC1 proficient cells upon cisplatin treatment alone or a combination of cisplatin and NU6027. Data represent mean values ±SEM (n = 6). Results were analysed using Students t-test. * p<0.05, ** p<0.01. <b>C.</b> FITC-Annexin V apoptosis assay is shown here. The proportion of cells in late phase apoptosis is higher in XRCC1 deficient cells treated with cisplatin alone or a combination of cisplatin and NU6027 compared to wild type cells.