Ventricular remodeling of hearts from 7-month-old NF or OF mice.

<p>A: Collagen density (% of area) of ventricular tissues from 7 months-old NF and OF mice. B: Representative picrosirius collagen staining of ventricular tissue from 7 months-old NF and OF mice., C: MMP-2 mRNA expression in myocardial tissues from 7 months-old NF and OF mice, measured by quantitative RT-PCR, D: Metalloproteinase activity in myocardial tissues from 7 months-old NF and OF mice, measured by gelatin zymography. P was calculated by Student’s <i>t</i>-test.