The analysis of HLA molecule restriction on CD8⁺ T-cell epitopes.

<p>The CD8⁺ T cell from donor 1 pre-sensitized with nonamer aa129–aa137 (A), donor 2 pre-sensitized with aa131–aa139 (B), donor 3 pre-sensitized with aa247–aa255 (C), and donor 4 pre-sensitized with aa167–aa175 (D) or aa277–aa285 (E) were tested against partially histocompatible EBV-B cells alone or pulsed with the particular peptide using <i>in vitro</i> IFN-γ ELISPOT assay. The HLA class I alleles shared between effectors and targets are indicated in ordinate. EBV-B, Epstein-barr virus-transformed B lymphoblast.