Allelic associations of SNPs in the <i>TLR7-TLR8</i> region with SLE.

<p>(A) The genomic structure of the <i>TLR7-TLR8</i> region and the location of all studied SNPs are indicated. (B) Association signals (−log₁₀<i>P</i>) are plotted against the position of each SNP (based on GRch37/hg19) in European Americans (EA), African Americans (AA), and Hispanics (HS). Genotyped and imputed SNPs are depicted with circles and triangles, respectively. The diamond identifies the <i>TLR7</i> 3′UTR SNP rs3853839. SNPs are highlighted using different colors according to their LD strength (r²) with rs3853839. (C) A trans-ancestral meta-analysis is conducted on 40 genotyped SNPs (circles) and 14 imputed SNPs (triangles) that are shared by the three ancestries (SNPs listed in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003336#pgen.1003336.s006" target="_blank">Table S1</a>) using fixed and random model, respectively. The dashed line represents the significance level of 5×10⁻⁸.