Comparison of the significance of individual haplotypes with the most significant SNPs in three regions on chromosomes 1, 4 and 18.

<p>These three regions, namely, (A) chr1∶8,309,317-8,318,147; (B) chr4∶122,325,743- 122,363,114; and (C) chr18∶35,670,316-35,683,522 were identified by the genome-wide haplotype association analysis using 5-SNP sliding windows. The regions were further extended both upstream and downstream by half of the original width to explore underdetected effects. Black circles denote individual haplotypes, the sizes of which are proportional to their haplotype frequencies. Red dots denote genotyped SNPs within the same region. Blue dot shows the most significant SNP.