Gene positioning and biological significance of the transcription-linked histone marks.

<p>The plots on the left represent the frequency (percentage) of transcription-linked histone marks that are characterized by their dynamic occupancy profiles with positive (r≥0.4) or negative (r≤−0.4) correlation with expression. The frequency of these transcription-linked profiles is plotted along an average gene corresponding to the genetic locus/probe positioning within the gene. In particular, the data was arranged into 500 bp bins ranging from 1500 bp upstream of the ATG start codon (“Promoter”) to +3000 bp into the gene (“Coding body”). The frequency (y-axis) is expressed as the percentage of transcription-linked profiles versus the total number of occupancy profiles (both dynamic and constitutive) for either positive (dark green, above the x-axis) or negative (light green, below the x-axis). The vertical dotted line marks the position of the ATG start codon. Functional enrichment analyses identified over-represented pathways (<i>P</i><0.05) as compared to their respective frequency in the genome for genes associated with each transcription-linked modification (right).