Effects of down-regulated Notch1 or Notch3 on the expression of CD44v6, E-cadherin, MMP-2, MMP-9, uPA, COX-2, ERK1/2, and p-ERK1/2 in HepG2 and MHCC97H cells.

<p>(a) The protein expression of CD44v6, E-cadherin, MMP-2, MMP-9, and uPA was measured by western blot analysis in differently treated HCC cells. (b) The protein expression of COX-2, ERK1/2 and p-ERK1/2 were measured by western blot analysis in differently treated HCC cells. NT: No transfection; Cs: control siRNA transfection; N1s: Notch1 siRNA transfection; N3s: Notch3 siRNA transfection.