<div><p>Transcription factor (TF)–induced reprogramming of somatic cells into induced pluripotent stem cells (iPSC) is associated with genome-wide changes in chromatin modifications. Polycomb-mediated histone H3 lysine-27 trimethylation (H3K27me3) has been proposed as a defining mark that distinguishes the somatic from the iPSC epigenome. Here, we dissected the functional role of H3K27me3 in TF–induced reprogramming through the inactivation of the H3K27 methylase EZH2 at the onset of reprogramming. Our results demonstrate that surprisingly the establishment of functional iPSC proceeds despite global loss of H3K27me3. iPSC lacking EZH2 efficiently silenced the somatic transcriptome and differentiated into tissues derived from the three germ ...
H3K27me3 is deposited at promoters by the preferential association of Polycomb repressive complex 2 ...
The Polycomb repressive complexes PRC1 and PRC2 act non-redundantly at target genes to maintain tran...
Through the histone methyltransferase EZH2, the Polycomb complex PRC2 mediates H3K27me3 and is assoc...
Transcription factor (TF)–induced reprogramming of somatic cells into induced pluripotent stem cells...
Current adress for Alessandro Blasimme: INSERM UMR 1027, Université de Toulouse 3-Paul SabatierInter...
Current adress for Alessandro Blasimme: INSERM UMR 1027, Université de Toulouse 3-Paul SabatierInter...
Current adress for Alessandro Blasimme: INSERM UMR 1027, Université de Toulouse 3-Paul SabatierInter...
Transcription factor (TF)-induced reprogramming of somatic cells into induced pluripotent stem cells...
Summary: The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through...
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation (H3K27me3), an e...
<div><p>Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation (H3K27me...
SummaryThe polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through i...
H3K27me3 is deposited at promoters by the preferential association of Polycomb repressive complex 2 ...
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation (H3K27me3), an e...
Background: Defining how epigenetic information is established in the germline during fetal developm...
H3K27me3 is deposited at promoters by the preferential association of Polycomb repressive complex 2 ...
The Polycomb repressive complexes PRC1 and PRC2 act non-redundantly at target genes to maintain tran...
Through the histone methyltransferase EZH2, the Polycomb complex PRC2 mediates H3K27me3 and is assoc...
Transcription factor (TF)–induced reprogramming of somatic cells into induced pluripotent stem cells...
Current adress for Alessandro Blasimme: INSERM UMR 1027, Université de Toulouse 3-Paul SabatierInter...
Current adress for Alessandro Blasimme: INSERM UMR 1027, Université de Toulouse 3-Paul SabatierInter...
Current adress for Alessandro Blasimme: INSERM UMR 1027, Université de Toulouse 3-Paul SabatierInter...
Transcription factor (TF)-induced reprogramming of somatic cells into induced pluripotent stem cells...
Summary: The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through...
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation (H3K27me3), an e...
<div><p>Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation (H3K27me...
SummaryThe polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through i...
H3K27me3 is deposited at promoters by the preferential association of Polycomb repressive complex 2 ...
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation (H3K27me3), an e...
Background: Defining how epigenetic information is established in the germline during fetal developm...
H3K27me3 is deposited at promoters by the preferential association of Polycomb repressive complex 2 ...
The Polycomb repressive complexes PRC1 and PRC2 act non-redundantly at target genes to maintain tran...
Through the histone methyltransferase EZH2, the Polycomb complex PRC2 mediates H3K27me3 and is assoc...