Effects of TIMP-3 peptides on VEGF-mediated EC proliferation.

<p>TIMP-3 loop 6 and tail but not loop 5 and N-peptide inhibit VEGF-induced proliferation in PAE/KDR cells. Serum-starved cells were incubated with or without VEGF (5 ng/ml) in the presence or absence of the 1 µM of TIMP-3 peptides for 5 days. Cell numbers were counted using a Coulter particle counter. **significantly different from control (with VEGF), p<0.01 (Student’s t test).