Inhibitors selective for HDAC6 in enzymes and cells
- Gupta, Praveer K.
- Reid, Robert C.
- Liu, Ligong
- Lucke, Andrew J.
- Broomfield, Steve A.
- Andrews, Melanie R.
- Sweet, Matthew J.
- Fairlie, David P.
Publication date
December 2010
DOI Publisher
Elsevier BV ISSN
0960-894X Citation count (estimate)
21Abstract
Histone deacetylase inhibitors with anticancer or anti-inflammatory activity bind to Class I or Class I and II HDAC enzymes. Here we compare selectivity of inhibitors of a Class II HDAC enzyme (HDAC6) and find one that retains high selectivity in macrophages. © 2010 Elsevier Ltd. All rights reserved
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