Sensory responses intracellularly recorded in S1 cortex neurons from non-epileptic Wistar rats and GAERS.

<p>Each panel depicts the sensory stimulus (top traces) and the corresponding responses in the EEG (middle records) and in a pyramidal neuron (bottom records) simultaneously recorded. (A1, B1) Typical examples of single sensory-evoked responses recorded from a control Wistar rat (A1) and in a GAERS (B1), during an interictal epoch (left) and during a seizure (right). The dashed boxes enclose the responses induced by whiskers deflection. (A2, B2) Superimposition (n = 4) of wERPs and corresponding suprathreshold intracellular responses (Supra-resp) in control (A2) and epileptic (B2) animals, during interictal (B2, left) and seizure (B2, right) periods. (A3, B3) Same representation as in A2 and B2 for neuronal responses that remained subthreshold in the three conditions. In A2, A3, B2, B3, the mean value of membrane potential at the onset of the cellular responses is indicated by the arrowheads. In A3 and B3, action potentials are truncated for clarity. Results depicted in A and B are from single neurons.