Effect of LTE₄ stimulation on cAMP and β-arrestin signalling pathways.

<p>Intracellular cAMP concentrations and β-arrestin recruitment was analysed in models of transiently transfected HEK293 or stably modified CHO cells, respectively. (A) [h-P2Y₁₂] and [Empty] transfectants were stimulated with forskolin and either ADP or LTE₄, N = 6, data expressed as % of forskolin stimulated control. (B) CHO cells expressing h-P2Y₁₂ and β-arrestin were stimulated with either 2-MeS-ADP or LTE₄, N = 9, expressed as relative luminescence units (RLU). Data represented as mean ± S.E.M. Two-way ANOVA with Bonferroni post-hoc test, *p<0.05.