Equivalent circuit modeling.

<p>a) The cell population is represented by the Cole-Cole model with an extracellular resistance (<i>R_extra</i>) in parallel to the tissue constant phase element (<i>CPE_cells</i>) and a high frequency intracellular current pathway (<i>R_intra</i>). The electrode/electrolyte interface is modeled by a constant phase element (<i>CPE_electrode</i>). A parallel capacitance (<i>C_par</i>) characterizes parasitic current shunts at high frequency. b) Impedance plot of MCF-7 cell culture. LF and HF refer to the low and high frequency respectively that were followed-up in this study. The equivalent circuit was used to fit the impedance and phase angle plots. (Weighted Sum of squares = 0.2247).