IL-17 was associated with immune complex deposition and complement activation in kidney.

<p>(A and B) Groups of BALB/c mice were treated with Ad-mIL-17 or Ad-Ctrl, and then immunized with 50 µg of ALD-DNA. Eight weeks later, the glomerular fluorescence was determined using anti-mouse IgG-FITC antibody or anti-mouse complement C3-FITC antibody. (C and D) Groups of BALB/c mice were injected with neutralizing antibody to IL-17 or the control antibody, and then immunized with 50 µg of ALD-DNA. Eight weeks later, the glomerular fluorescence was determined using anti-mouse IgG-FITC antibody or anti-mouse complement C3-FITC antibody. (E and F) Groups of IL-17^−/− mice or WT mice were immunized with 50 µg of ALD-DNA. Eight weeks later, the glomerular fluorescence was determined using anti-mouse IgG-FITC antibody or anti-mouse complement C3-FITC antibody. The fluorescence image shown was the representative result. The data of fluorescence intensity represented means (±SD) for eight mice in each group. *P<0.05.