Inverse association between sequence divergence rates and nucleosome occupancy around splicing sites.

<p>The left panel shows genetic variation rates (blue: substitution, red: indel) and H2A.Z nucleosome occupancy (gray area) around acceptor sites. The right panel shows the case around donor sites. H2A.Z is enriched within exons with a well-positioned nucleosome at both borders, and largely depleted inside introns. Contrary to this, sequence variation rates are very low within exons and precipitously increase inside introns.