Co-mapping of dose-related metabolite changes with metabolic schemes.

<p>A- Glutathione cycle and metabolism. Abbreviations: GS-X, conjugated GSH; GSSG, oxidized GSH; GS-L, lactoyl-glutathione; Glu-Cys, glutamylcysteine; Cys, cysteine; Met, methionine; Ser, serine; GST, glutathione <i>S-</i>transferase; GSR, glutathione <i>S-</i>reductase; GLO1, glyoxalase-1; GS, glutathione synthetase; GCL, glutamate-cysteine ligase; OPase, oxoprolinase, CBS, cystathionine beta-synthase. Other metabolite abbreviations, as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057971#pone-0057971-t001" target="_blank">Table 1</a>. Italicized, enzymes; Grey, undetected/unmeasured metabolites; #, P<0.05; *, P<0.025; $, P<0.01, Mann-Whitney test. B- Glycolysis and lipid metabolism. Abbreviations: PtE, phosphatidylethanolamine; Glc, glucose; DAG, diacylglycerol; Pyr, pyruvate; ACoA, acetyl-CoA; PG, prostaglandin; CHK, choline kinase; CCT, choline cytidylyltransferase; PDH, pyruvate dehydrogenase; PLA₂, phospholipase A₂; FASN, fatty acid synthase; COX-2, cyclooxygenase-2. Other metabolite abbreviations, as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057971#pone-0057971-t001" target="_blank">Table 1</a>. #, P<0.05; *, P<0.025; $, P<0.01, Mann-Whitney test.