The values and descriptions of the parameters used in the simulations.

<p>The values were calibrated for each network using the passive vaccination approach.</p><p>* The values , and were calibrated such that the average annual vaccine coverage on each network was approximately using appropriate values.</p>**<p> was used in calibrating influenza incidence () using values similar to influenza's <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002945#pcbi.1002945-Mao1" target="_blank">[40]</a>–<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002945#pcbi.1002945-Couch1" target="_blank">[42]</a> on each network such that the average peak of prevalence occurred between January and February <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002945#pcbi.1002945-CDC3" target="_blank">[66]</a>.</p>†<p>The value for was calculated such that the annual incidence of non-influenzal influenza-like-illness (niILI) was , corresponding to the ratio of niILI incidence to influenza incidence estimated in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002945#pcbi.1002945-Fleming1" target="_blank">[62]</a> and multiplied by the average annual influenza incidence () <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002945#pcbi.1002945-Wells1" target="_blank">[37]</a>, <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002945#pcbi.1002945-Mao1" target="_blank">[40]</a>–<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002945#pcbi.1002945-Couch1" target="_blank">[42]</a>.</p>††<p>The variance for was calibrated such that the log-normal distribution best resembled the shape of a normal distribution.</p>◊<p> was computed as the cost of the actual vaccination and plus the time required to receive the vaccination .