RvD1 reduces CS-induced neutrophilic lung inflammation.

<p>Lungs from mice that had <i>not</i> been lavaged were inflated and fixed with neutral buffered formalin, and 5 µm paraffin sections were stained with a neutrophil-specific antibody (brown) and counter-stained with hematoxylin. An occasional neutrophil was observed in air-exposed mice treated with RvD1 (<b>A, B</b>), similar to air-exposed mice treated with vehicle (not shown). CS induces a neutrophilic inflammation around vessels and airways (<b>C</b>) and in the parenchyma (<b>D</b>), with neutrophils prominent in the interstitial spaces (arrows) and the alveoli (solid triangles). RvD1 treatment reduces perivascular and peribronchial (<b>E</b>) as well as parenchymal (<b>F</b>) accumulation of neutrophils. A, airway; v, vessel. Arrows, interstitial neutrophils; solid triangles, neutrophils in airspaces.