Time course of phospho-JNK expression in the cochlear lysate following exposure to the intense noise.

<p>The levels of phospho-JNK in the cochlear lysate at 0 h (immediately after the noise exposure; 104.7±7.6), 3 h (167.2±18.1; <i>p</i><0.01), 6 h (146.4±13.3; <i>p</i><0.01), 12 h (129.2±10.8; <i>p<</i>0.01), 24 h (127.1±11.8; <i>p<</i>0.01), and 48 h (185.4±13.8; <i>p<</i>0.01) after the noise exposure significantly increased from the control level (100.0±11.8), with the early and late peaks at 3 h and 48 h. (*<i>p</i><0.01, Kruskal-Wallis test and Mann-Whitney <i>U</i>-test; <i>n</i> = 8 for each time point).