Topography, Rac1 and ROCK inhibition synergistically affect osteoblast deposition of BSP and OCN.

<p>(a) representative images of tetracycline, osteocalcin and BSP on SLA surfaces at 4 weeks post seeding (PT showed same pattern, not shown). (b) Quantification of BSP and OCN labeling at 4 weeks post seeding. Images are representative of triplicates from three experiments. Treatments were analyzed via two-way ANOVA with a Bonferroni post-test (# denotes significance of p<0.05 between PT and SLA, * denotes significance of p<0.05 between treatments within a surface type).